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Extra virgin olive oil is a key component of both the Mediterranean and Mind diets, and research shows that it may help prevent dementia. Photo: Shutterstock

How extra virgin olive oil may help prevent dementia, and its other health benefits

  • Extra virgin olive oil helps clear toxic proteins that are markers of Alzheimer’s disease, study suggests, and has anti-inflammatory effects
Wellness
This is the 39th instalment in a series on dementia, including the research into its causes and treatment, advice for carers, and stories of hope.

You might have heard of the Mediterranean diet and the Mind (Mediterranean-Dash Intervention for Neurodegenerative Delay) diet. Both are good for our brains, with plenty of scientific evidence to back this up.

The Alzheimer’s Society in the UK reported that sticking to a Mediterranean diet could reduce a person’s dementia risk by up to 23 per cent, while research published earlier this year found that both diets could help to preserve some cognitive abilities in midlife, particularly elements of memory.
The Mediterranean diet is based on the eating habits of people in countries bordering the Mediterranean Sea, including Italy, Spain and Greece. Two of the world’s five blue zones – areas where people live, and live well, to over 100 years old – are in this region: Sardinia in Italy and Ikaria in Greece.
Olive oil needs to have been cold-pressed from the fruit to be “certified” extra virgin. Photo: Shutterstock
The Mediterranean diet was ranked the best diet for health in the US News & World Report’s Best Diets 2024 list.
The Mind diet – which combines the Mediterranean diet and the Dash (Dietary Approaches to Stop Hypertension) diet – was conceived in 2015 by the late Martha Clare Morris at the Harvard TH Chan School of Public Health, and designed with brain health in mind.

Together with her daughter, Laura, Morris wrote The Official Mind Diet: A Scientifically Based Program to Lose Weight and Prevent Alzheimer’s Disease, which was published in 2023.

Researchers have compared all three diets – Mediterranean, Mind and Dash – for their brain benefits. They all offer some, but the Mind diet stands out, with up to a 53 per cent reduced risk of developing Alzheimer’s disease, according to research published in the Alzheimer’s & Dementia journal.
Though similar, there are important differences between the Mind and the Mediterranean diets. The Mind diet prioritises green, leafy vegetables like spinach and kale, and it lauds berries over other fruit. The Mediterranean diet suggests eating more fish and seafood than the Mind diet, and includes cheese, which the Mind diet does not.
Martha Clare Morris (left) and her daughter Laura co-authored The Official Mind Diet: A Scientifically Based Program to Lose Weight and Prevent Alzheimer’s Disease. Photo: Laura Morris
There is one key ingredient that holds fast for both diets: olive oil. And quite a lot of it.
“Extra virgin olive oil is a key component of the Mediterranean diet, as well as the Mind diet,” Laura Morris says. “Extra virgin olive oil [EVOO] is thought to have protective effects against dementia by providing high amounts of unsaturated fats, along with anti-inflammatory and antioxidant properties. The Mind diet recommends 2 tablespoons per day of high-quality EVOO.”

For the Mediterranean diet, one to four tablespoons a day is the general recommendation.

Olive oil has been a mainstay of diets in the Mediterranean for millennia. The earliest surviving olive oil amphorae – the traditional jugs in which oil was stored – date back to 3500BC, which means production started even earlier. The Greek poet Homer called olive oil “liquid gold”, while the “father of medicine”, Hippocrates, called it “the great healer”.

It seems the scientists of today agree. Neuropathologist Dr Domenico Praticò, a professor and director of the Alzheimer’s Centre at Temple University, in the US state of Pennsylvania, is a co-author of a study that found that EVOO may help prevent Alzheimer’s disease by activating autophagy inside nerve cells.

Autophagy, he explained, destroys unwanted materials that accumulate inside cells. He said to think of it as the “garbage disposal in a sink. The moment that it does not work, the sink will be clogged.”

One way to incorporate olive oil in your diet is to drizzle it on bread, instead of using butter. Photo: Shutterstock
When EVOO activates autophagy, it leads to the digestion of amyloid and tau proteins that are a marker of Alzheimer’s. It also helps to reduce inflammation of the brain and improve communication between nerve cells, he says.

Olive oil could be protective because it contains powerful antioxidants called polyphenols. Two that are abundant in olive oil are hydroxytyrosol and oleocanthal. These have a potent anti-inflammatory effect that has been compared to that of the drug ibuprofen.

A study published in May reflected these brain-protective findings: it found a higher olive oil intake was associated with a lower risk of dementia-related deaths.

One of the senior authors on the study, Marta Guasch-Ferré, an adjunct associate professor in the department of nutrition at the Harvard TH Chan School of Public Health, and an associate professor in the department of public health at the University of Copenhagen, in Denmark, explains why.

“Some antioxidant compounds in olive oil can cross the blood-brain barrier, potentially having a direct effect on the brain. It is also possible that olive oil has an indirect effect on brain health by benefiting cardiovascular health.”
Marta Guasch-Ferré says some antioxidant compounds in olive oil can cross the blood-brain barrier. Photo: Marta Guasch-Ferré

In US adults, she continues, her research team found that those who consumed more than half a tablespoon of olive oil per day had a 28 per cent lower risk of dying from dementia compared to those who never or rarely consumed olive oil.

“Typically, people who use olive oil for cooking or as a dressing have an overall better quality of their diet … We also found that replacing one teaspoon of margarine and mayonnaise with the equivalent amount of olive oil was associated with an 8 to 14 per cent lower risk of dying from dementia,” she says.

Another study, which monitored the effects of an even heftier olive oil dose – up to 50g a day (equivalent to roughly 3.5 tablespoons) – found that regular consumption came with beneficial effects on the gut microbiota, which positively influences many processes in the body, from cardiovascular to cognitive health.

The key in all of these studies, though, is extra virgin olive oil.

Olive oil qualifies as extra virgin if it is unrefined – meaning it has not been exposed to chemical or heat treatment. It needs to have been cold-pressed from the fruit to be “certified” extra virgin. Regular olive oil (as opposed to extra virgin) is a blend of refined and unrefined olive oils.

Olive oil and vegetables feature prominently in both the Mediterranean and Mind diets. Photo: Shutterstock

Because extra virgin olive oil has not been refined, it has a lower smoke point, which means it burns at a lower temperature than, say, corn oil. But it is not true that olive oil cannot be used for sautéing or frying; it can, and it can be a healthier option to do so than other oils.

5 ways to incorporate olive oil into your daily diet

No one, except possibly biohacker Bryan Johnson, suggests downing three or four tablespoons of olive oil a day neat. Here are some simple ways to enjoy it, from the Olive Wellness Institute in Australia and Israel’s Holive Oil.

  1. Drizzle your morning toast with it instead of butter

  2. Splash it over a plate of tomato slices with a pinch of salt and a twist of black pepper, or add a spoon to soup before serving

  3. Use it in home-made salad dressings

  4. Use it for stir-fry recipes – just heat slowly and carefully

  5. Bake with it – cakes made using olive oil in place of butter tend to be especially moist

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